منابع مشابه
Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملSome new biosynthetic penicillins.
In our laboratories some 200 compounds, including phenylacetic acid derivatives, have been studied as possible precursors for new penicillins, and several of these appeared to give rise to new penicillins. In this report, five new penicillins, four of which were obtained in crystalline form, are described and their production, isolation, and characterization discussed. The methods employed in o...
متن کاملThe New Penicillins in Endocarditis.
FEW infections can kill a human being as rapidly as acute staphylococcal endocarditis in its most fulminant form. Infections caused by penicillinase producing staphylococci have been particularly difficult to manage. Successful treatment has been 'accomplished by combinations of antibiotics, by vancomycin, and even by huge doses of penicillin G. Still, the problem of therapy remains formidable....
متن کاملAzlocillin and mezlocillin: new ureido penicillins.
The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 82% of Bacteroides strains tested. Mezlocillin inhibited 86% of Shigella, 96% o...
متن کاملPenicillins and cephalosporins.
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
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ژورنال
عنوان ژورنال: BMJ
سال: 1964
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5414.940-a